《未来的光防护：挑战与机遇》共识解读：国际防晒化妆品发展趋势及对中国的启示

doi:10.35541/cjd.20200567

中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (12): 962-966.doi: 10.35541/cjd.20200567

《未来的光防护：挑战与机遇》共识解读：国际防晒化妆品发展趋势及对中国的启示

赖维¹ 郑跃¹ Corinne Granger² Carles Trullas² Jean Krutmann³ 刘玮⁴

¹中山大学附属第三医院皮肤科，广州 510630；²Innovation and Development ISDIN， 08000 Barcelona，Spain；³IUF-Leibniz Research Institute for Environmental Medicine，40210 Düsseldorf，Germany；⁴解放军空军特色医疗中心皮肤科，北京 100036

收稿日期:2020-06-09 修回日期:2020-10-21 发布日期:2020-12-02
通讯作者: 赖维 E-mail:drlaiwei@163.com

Explanation and elaboration of the consensus “photoprotection of the future: challenges and opportunities”: international development trends of sunscreen cosmetics and their enlightenment to China

Lai Wei¹, Zheng Yue¹, Corinne Granger², Carles Trullas², Jean Krutmann³, Liu Wei⁴

¹Department of Dermatology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China; ²Innovation and Development ISDIN, 08000 Barcelona, Spain; ³IUF-Leibniz Research Institute for Environmental Medicine, 40210 Düsseldorf, Germany; ⁴Department of Dermatology, Air Force Medical Center, Beijing 100036, China

Received:2020-06-09 Revised:2020-10-21 Published:2020-12-02
Contact: Lai Wei E-mail:drlaiwei@163.com

摘要/Abstract

摘要： 【摘要】目前对防晒化妆品的认识还存在一些误区,如防晒系数越高越好，防晒剂可以引起使用者缺钙等。防晒化妆品也存在诸如防晒系数测定和标识方法不统一、防护波长范围不足、对人体及环境的安全性不明等许多问题和挑战。本文阐述国际上防晒化妆品面临的问题、发展趋势及对中国防晒化妆品研发的启示等，供临床医师参考。

关键词: 防晒剂, 防晒系数, 毒性作用, 趋势

Abstract: 【Abstract】 At present, there are still some misunderstandings regarding sunscreen cosmetics. For example, the higher the sun protection factor, the better the sunscreen cosmetics, and sunscreen agents can cause calcium deficiency in users. As far as sunscreen cosmetics are concerned, there are also many problems, concerns and challenges, such as inconsistent testing and labeling methods for sun protection factor, insufficient protection wavelength range, and unclear safety to the human body and environment. This article describes global issues in sunscreen cosmetics, their development trends, and enlightenment to the research and development of sunscreen cosmetics in China, aiming to provide a reference for clinicians.

Key words: Sunscreening agents, Sun protection factor, Toxic actions, Trends

赖维郑跃 Corinne Granger Carles Trullas Jean Krutmann 刘玮. 《未来的光防护：挑战与机遇》共识解读：国际防晒化妆品发展趋势及对中国的启示[J]. 中华皮肤科杂志, 2020,53(12):962-966. doi:10.35541/cjd.20200567

Lai Wei, Zheng Yue, Corinne Granger, Carles Trullas, Jean Krutmann, Liu Wei. Explanation and elaboration of the consensus “photoprotection of the future: challenges and opportunities”: international development trends of sunscreen cosmetics and their enlightenment to China[J]. Chinese Journal of Dermatology, 2020, 53(12): 962-966.doi:10.35541/cjd.20200567

参考文献 35

［1］	Krutmann J, Passeron T, Gilaberte Y, et al. Photoprotection of the future: challenges and opportunities［J］. J Eur Acad Dermatol Venereol, 2020,34（3）:447⁃454. doi: 10.1111/jdv.16030.
［2］	Krutmann J. Ultraviolet A radiation⁃induced biological effects in human skin: relevance for photoaging and photodermatosis［J］. J Dermatol Sci, 2000,23 Suppl 1:S22⁃S26. doi: 10.1016/s0923⁃1811（99）00077⁃8.
［3］	van der Pols JC, Williams GM, Pandeya N, et al. Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use［J］. Cancer Epidemiol Biomarkers Prev, 2006,15（12）:2546⁃2548. doi: 10.1158/1055⁃9965.EPI⁃06⁃0352.
［4］	Boukari F, Jourdan E, Fontas E, et al. Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial［J］. J Am Acad Dermatol, 2015,72（1）:189⁃190.e1. doi: 10.1016/j.jaad.2014.08.023.
［5］	Duteil L, Esdaile J, Maubert Y, et al. A method to assess the protective efficacy of sunscreens against visible light⁃induced pigmentation［J］. Photodermatol Photoimmunol Photomed, 2017,33（5）:260⁃266. doi: 10.1111/phpp.12325.
［6］	Schalka S. New data on hyperpigmentation disorders［J］. J Eur Acad Dermatol Venereol, 2017,31 Suppl 5:18⁃21. doi: 10.1111/jdv.14411.
［7］	Schroeder P, Lademann J, Darvin ME, et al. Infrared radiation⁃induced matrix metalloproteinase in human skin: implications for protection［J］. J Invest Dermatol, 2008,128（10）:2491⁃2497. doi: 10.1038/jid.2008.116.
［8］	Wolber R, Schlenz K, Wakamatsu K, et al. Pigmentation effects of solar⁃simulated radiation as compared with UVA and UVB radiation［J］. Pigment Cell Melanoma Res, 2008,21（4）:487⁃491. doi: 10.1111/j.1755⁃148X.2008.00470.x.
［9］	Autier P, Doré JF. Ultraviolet radiation and cutaneous melanoma: a historical perspective［J］. Melanoma Res, 2020,30（2）:113⁃125. doi: 10.1097/CMR.0000000000000609.
［10］	Battie C, Jitsukawa S, Bernerd F, et al. New insights in photoaging, UVA induced damage and skin types［J］. Exp Dermatol, 2014,23 Suppl 1:7⁃12. doi: 10.1111/exd.12388.
［11］	Mahmoud BH, Ruvolo E, Hexsel CL, et al. Impact of long⁃wavelength UVA and visible light on melanocompetent skin［J］. J Invest Dermatol, 2010,130（8）:2092⁃2097. doi: 10.1038/jid. 2010.95.
［12］	Kohli I, Chaowattanapanit S, Mohammad TF, et al. Synergistic effects of long⁃wavelength ultraviolet A1 and visible light on pigmentation and erythema［J］. Br J Dermatol, 2018,178（5）:1173⁃1180. doi: 10.1111/bjd.15940.
［13］	Regazzetti C, Sormani L, Debayle D, et al. Melanocytes sense blue light and regulate pigmentation through opsin⁃3［J］. J Invest Dermatol, 2018,138（1）:171⁃178. doi: 10.1016/j.jid.2017. 07.833.
［14］	Passeron T, Picardo M. Melasma, a photoaging disorder［J］. Pigment Cell Melanoma Res, 2018,31（4）:461⁃465. doi: 10.1111/pcmr.12684.
［15］	Passeron T, Nouveau S, Duval C, et al. Development and validation of a reproducible model for studying post⁃inflammatory hyperpigmentation［J］. Pigment Cell Melanoma Res, 2018,31（5）:649⁃652. doi: 10.1111/pcmr.12692.
［16］	Passeron T. The key question of irradiance when it comes to the effects of visible light in the skin［J］. J Dermatol Sci, 2019,93（1）:69⁃70. doi: 10.1016/j.jdermsci.2018.11.011.
［17］	Grether⁃Beck S, Marini A, Jaenicke T, et al. Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: results from a vehicle controlled, double⁃blind, randomized study［J］. Photochem Photobiol, 2015,91（1）:248⁃250. doi: 10.1111/php.12375.
［18］	Osterwalder U, Herzog B. Sun protection factors: world wide confusion［J］. Br J Dermatol, 2009,161 Suppl 3:13⁃24. doi: 10.1111/j.1365⁃2133.2009.09506.x.
［19］	Trullàs C, Granger C, Lim HW, et al. Linear and exponential sunscreen behaviours as an explanation for observed discrepancies in sun protection factor testing［J］. Photodermatol Photoimmunol Photomed, 2019,36（5）:351⁃366. doi: 10.1111/phpp.12500.
［20］	Damian DL, Halliday GM, Stc Barnetson R. Sun protection factor measurement of sunscreens is dependent on minimal erythema dose［J］. Br J Dermatol, 1999,141（3）:502⁃507. doi: 10. 1046/j.1365⁃2133.1999.03045.x.
［21］	Rohr M, Ernst N, Schrader A. Hybrid diffuse reflectance spectroscopy: non⁃erythemal in vivo testing of sun protection factor［J］. Skin Pharmacol Physiol, 2018,31（4）:220⁃228. doi: 10.1159/000488249.
［22］	Pissavini M, Tricaud C, Wiener G, et al. Validation of an in vitro sun protection factor （SPF） method in blinded ring⁃testing［J］. Int J Cosmet Sci, 2018. doi: 10.1111/ics.12459.
［23］	Schieke SM, Ruwiedel K, Gers⁃Barlag H, et al. Molecular crosstalk of the ultraviolet a and ultraviolet B signaling responses at the level of mitogen⁃activated protein kinases［J］. J Invest Dermatol, 2005,124（4）:857⁃859. doi: 10.1111/j.0022⁃202X.2005.23671.x.
［24］	Liu W, Wang X, Lai W, et al. Sunburn protection as a function of sunscreen application thickness differs between high and low SPFs［J］. Photodermatol Photoimmunol Photomed, 2012,28（3）:120⁃126. doi: 10.1111/j.1600⁃0781.2012.00650.x.
［25］	Matta MK, Zusterzeel R, Pilli NR, et al. Effect of sunscreen application under maximal use conditions on plasma concentration of sunscreen active ingredients: a randomized clinical trial［J］. JAMA, 2019,321（21）:2082⁃2091. doi: 10. 1001/jama.2019.5586.
［26］	Nohynek GJ, Dufour EK. Nano⁃sized cosmetic formulations or solid nanoparticles in sunscreens: a risk to human health?［J］. Arch Toxicol, 2012,86（7）:1063⁃1075. doi: 10.1007/s00204⁃012⁃0831⁃5.
［27］	Schneider SL, Lim HW. A review of inorganic UV filters zinc oxide and titanium dioxide［J］. Photodermatol Photoimmunol Photomed, 2019,35（6）:442⁃446. doi: 10.1111/phpp.12439.
［28］	Passeron T, Bouillon R, Callender V, et al. Sunscreen photoprotection and vitamin D status［J］. Br J Dermatol, 2019,181（5）:916⁃931. doi: 10.1111/bjd.17992.
［29］	Neale RE, Khan SR, Lucas RM, et al. The effect of sunscreen on vitamin D: a review［J］. Br J Dermatol, 2019,181（5）:907⁃915. doi: 10.1111/bjd.17980.
［30］	Cranwell WC, Sinclair R. Sunscreen and facial skincare products in frontal fibrosing alopecia: a case⁃control study［J］. Br J Dermatol, 2019,180（4）:943⁃944. doi: 10.1111/bjd.17354.
［31］	Moreno⁃Arrones OM, Saceda⁃Corralo D, Rodrigues⁃Barata AR, et al. Risk factors associated with frontal fibrosing alopecia: a multicentre case⁃control study［J］. Clin Exp Dermatol, 2019,44（4）:404⁃410. doi: 10.1111/ced.13785.
［32］	Mitchelmore CL, He K, Gonsior M, et al. Occurrence and distribution of UV⁃filters and other anthropogenic contaminants in coastal surface water, sediment, and coral tissue from Hawaii［J］. Sci Total Environ, 2019,670:398⁃410. doi: 10.1016/j.scitotenv.2019.03.034.
［33］	Schneider SL, Lim HW. Review of environmental effects of oxybenzone and other sunscreen active ingredients［J］. J Am Acad Dermatol, 2019,80（1）:266⁃271. doi: 10.1016/j.jaad.2018. 06.033.
［34］	Narda M, Ramos⁃Lopez D, Mun G, et al. Three⁃tier testing approach for optimal ocular tolerance sunscreen［J］. Cutan Ocul Toxicol, 2019,38（3）:212⁃220. doi: 10.1080/15569527.2019.160 1106.
［35］	Wang SQ, Virmani P, Lim HW. Consumer acceptability and compliance: the next frontier in sunscreen innovation［J］. Photodermatol Photoimmunol Photomed, 2016,32（1）:55⁃56. doi: 10.1111/phpp.12211.

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《未来的光防护：挑战与机遇》共识解读：国际防晒化妆品发展趋势及对中国的启示

Explanation and elaboration of the consensus “photoprotection of the future: challenges and opportunities”: international development trends of sunscreen cosmetics and their enlightenment to China

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