中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (7): 573-576.doi: 10.35541/cjd.20191042
姜集聪1,吴建洺1,高宇2
收稿日期:
2019-10-31
修回日期:
2020-05-22
发布日期:
2020-07-06
通讯作者:
高宇
E-mail:gaoyu0570@163.com
基金资助:
Ji cong Jiang1,Jianming Wu1,
Received:
2019-10-31
Revised:
2020-05-22
Published:
2020-07-06
Supported by:
摘要: 【摘要】 普萘洛尔是非选择性β肾上腺素受体阻滞剂,多项研究已证实其治疗婴儿血管瘤安全有效,作用机制主要包括:①由周细胞介导的血流动力学改变及后续效应;②阻滞血管瘤来源的内皮细胞和干细胞的细胞周期进程从而抑制其增殖,诱导血管瘤来源的内皮细胞凋亡和血管瘤来源的干细胞向脂肪细胞分化;③抑制内皮祖细胞的募集;④降低促血管生成因子(如血管内皮生长因子、基质金属蛋白酶等)的水平。
姜集聪 吴建洺 高宇. 普萘洛尔治疗婴儿血管瘤的研究进展[J]. 中华皮肤科杂志, 2020,53(7):573-576. doi:10.35541/cjd.20191042
Ji cong Jiang Jianming Wu. Propranolol for the treatment of infantile hemangioma[J]. Chinese Journal of Dermatology, 2020, 53(7): 573-576.doi:10.35541/cjd.20191042
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