Abstract: In this article,5 cases of histoid leproma(HL) occurred in different conditions of leprosy were studied by TEM in connection with clinical manifestation and histopathological picture.Two of them were examined by SEM.The results were as follows:The cellular components of HL were similar to those being described formerly,including 4 of macrophages(i.e.ordinary,fusiform,epithelioid types and foamy macrophages).