Abstract: HLA-DR typing performed in 69 patients of Jiangsu Han nationality with leprosy including 37 cases of lepromatous type(LL and BL) and 32 cases of tnbercnloid type(TT and BT),togetheiwith 65 healthy controls of the same nationality matched for locality, age and sex.Three groups of the leprosy patients(all patient, lepromatous patient and tuberculoid patient) were compared with the healthy controls respectively.