Abstract: Objective To analyze the therapeutic outcomes and adverse effects of high-dose intravenous immunoglobulin (hd-IVIg) in the treatment of some severe skin diseases (toxic epidermal necrolysis,drug hypersensitivity syndrome,connective tissue disease,autoimmune bullous disease,acute graft-versus-host disease).Methods Twenty-five cases of severe skin diseases were treated with hd-IVIg (0.4 g/kg/day for a course of 5 days).Results The therapeutic outcomes were different from each other.Of all the cases,21 improved,especially those of acute onset of toxic epidermal necrolysis and drug hypersensitivity syndrome;1 adult dermatomyositis and 2 elder bullous pemphigoid were not relieved.A patient with acute graft-versus-host disease died.Three patients presented with minor adverse effects (headache and blood pressure rising).Conclusions hd-IVIg is effective and safe in the treatment of some severe skin diseases.More importantly,it has a substantial effect on shortening disease course and decreasing the dosage of glucocorticoids and immunosuppressants as well as on preventing infections.

Key words: Immunoglobulin, Epidermal necrolysis,toxic, Drug hypersensitivity, Connective tissue diseases, Skin disease,bullous, Graftvshost disease