聚合酶链反应检测结节病皮损中的结核杆菌DNA

Chinese Journal of Dermatology ›› 1995, Vol. 28 ›› Issue (5): 299-300.

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Detection of Mycobacterium Tuberculosis DNA from the Skin Lesion of Sarcoidosis by Polymerase Chain Reaction

Li Ning, Tu Ping, Ma Shengqing

Department of Dermatology, First Teaching Hospital, Beijing Medical University, Beijing 100034

Received:1994-10-28 Revised:1995-01-26 Online:1995-10-15 Published:1995-10-15

Abstract

Abstract: The cause of sarcoidosis is still unknown.However,the histological similarity between the disorder and tuberculosis suggests that M.tuberculosis might contribute to the pathogenesis of sarcoidosis.In attempting to confirm the relation between M.tuberculosis and sarcoidosis,we used the polymerase chain reaction to detect M.tuberculosis DNA from formalin-fixed,paraffin-embeded skin biopsy specimens of 12 patients with sarcoidosis,M.tuberculosis DNA was found in 4 patients.This finding suggests an aetiological role for M.tuberculosis in sarcoidosis.

Key words: Scarcoidosis, M.tuberculosis, PCR

Li Ning, Tu Ping, Ma Shengqing. Detection of Mycobacterium Tuberculosis DNA from the Skin Lesion of Sarcoidosis by Polymerase Chain Reaction[J].Chinese Journal of Dermatology, 1995, 28(5): 299-300.

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Detection of Mycobacterium Tuberculosis DNA from the Skin Lesion of Sarcoidosis by Polymerase Chain Reaction

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