Chinese Journal of Dermatology ›› 1996, Vol. 29 ›› Issue (5): 333-334.

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Study on the Induction of Skin Cancer by Coal Tar Pitch Smoke in Mice

Wang Ying1, Zhang Shuling1, Wang Jiang2   

  1. Department of Dermatology, People's Hospital of Henan Province, Zhengzhou 450003
  • Received:1995-11-16 Revised:1996-02-12 Online:1996-10-15 Published:1996-10-15

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Abstract: In this study,100 mice were divided into two groups(group A and B)to study the carcinogenic effect of pitch smoke on skin.Mice in group A were exposed to coal tar pitch smoke(CTPS) 3 hours a day in a box 6 days per week.The average concentration of CTPS in the box was 0.17mg/L. The duration of exposure was 4 months.These mice were followed up for another 4 months.Group B was designed as a control.After eight months,skin neoplasms were found in 40 mice(83.33%)in group A,of which squamous cell carcinomas were found in 32 mice(66.67%).Lymph node metastasis of the carcinoma was found in 8 mice.No skin tumor was found in group B.The result of present study shows that CTPS has strong carcinogenic effect on skin.

Key words: Pitch, Cancer,skin