Chinese Journal of Dermatology ›› 2000, Vol. 33 ›› Issue (4): 249-250.

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Vitiligo Treated by Transplantation of Autologous Noncultured Epidermal Cell Suspension

XU Aie, WEI Xiaodong, CHENG Dongqing   

  1. Department of Dermatology, Third People's Hospital of Hangzhou, Hangzhou 310009
  • Received:1999-10-08 Online:2000-08-15 Published:2000-08-15

Abstract: Objective To establish a therapeutic method by transplantation of autologous noncultured epidermal cell suspension for the treatment of vitiligo. Methods The shave biopsy specimens of gluteal skin were trypsinized and epidermal cell suspension was prepared.The noncultured epidermal cell suspension was transplanted into a liquid nitrogen induced blister at the depigmented lesion. A total of 24 cases of vitiligo with lesions in stable stage were treated. Results Successful repigmentation was obtained in 23 of 24 patients, with the maximum repigmented area of 150 cm2. The repigmented areas accounted for 62%~93% of depigmented lesions in 14 patients after the first transplantation, and increased to 85%~97% in 9 patients with a second transplantation. After a follow up of 6 months, the repigmented areas sustained except two patients whose lesions became depigmented again in 1~3 months after repigmentation. One patient failed to response. Conclusion This technique of transplantation of autologous noncultured epidermal cell suspension appears to be an effective and simple method for treating patients with vitiligo in stable stage.

Key words: Vitiligo, Transplantation