Abstract: Objective To study the role of serum chemokines and their receptors in the pathogenesis of condyloma acuminatum(CA).Methods Serum levels of interleukin 8(IL-8),interferon γ-inducible protein 10(IP-10),monocyte chemotactic protein 1(MCP-1),macrophage inflammatory protein 1α(MIP-1α),regulated upon activation,normal T cell expressed and secreted factor(RANTES)and macrophage-derived chemokine(MDC)were determined by enzyme-linked immunosorbent assay(ELISA)in 30 patients with CA and 30 normal controls.Meanwhile,chemokine receptors,CXCR1,CXCR3,CCR2 and CCR5 on peripheral blood CD3⁺T-lymphocytes from 20 patients with CA were analyzed by flow cytometry with two-color im-munofluorescent staining.Results Serum levels of IP-10 and MIP-1α were significantly higher in CA patients than those in controls(P<0.02 and P<0.05,respectively).There was no significant difference in the serum levels of IL-8,MCP-1,RANTES and MDC between the patients and controls.The number of CXCR1-positive T cells in peripheral blood increased in patients with CA compared to controls(P<0.05).Conclusions Serum levels of IP-10,MIP-1α and the number of CXCR1⁺T cells in peripheral blood were significantly high-er in patients with CA,which are related to the recurrence and the course of disease.IP-10 and MIP-1α may play an important role in nonspecific antiviral immune response in human body.

Key words: Condylomata acuminata, Chemokines, Receptors,chemokine