Abstract:

Experimental Study on Blood-Stage Treatment on Influencing IL-17、 IL-23 in Patients with Psoriasis Vulgaris CHEN Jin-guang.Department of Dermatology,Zhe Jiang Tai Zhou Municipal Hospital,Taizhou 318000, China. ZHU Ming-fang,YANG Zhi-bo. Second Affiliated Hospital Hunan Chinese Medical College, Chang Sha 410005,hunan, China. Abstract: Objective：To investigate the action mechanisma of blood-stage treatment in the influence of psoriasis vulgaris from Th17. Methods:32 patients were observed and 15 healthy people were enrolled as control. Th17-related plasma cytokine(IL-17、IL-23) concentrations were measured by enzyme-linked immunosorbent assay(ELISA) before and after treated by heat-clearing and blood-cooling decoction、qi-enriching and blood-activating decoction. Results: Th17 related cytokine IL-17 and IL-23 markedly increased in psoriasis compared with controls.After herbal treatment, IL-17、IL-23 expression decreased.Conclusion: Blood-stage treatment works well on IL-17、IL-23 expression in patients with psoriasis vulgaris.

Key words: IL-23