Abstract:

Objective To investigate the role and clinical significance of interferon regulatory factor 7 （IRF7） and Toll-like receptor 9 （TLR9） in the development of condyloma acuminatum （CA）. Methods Reverse transcription-PCR was performed to analyze the mRNA expressions of IRF7 and TLR9 in peripheral blood mononuclear cells （PBMCs） of 25 patients with CA and 20 normal human controls. Results The expression levels of IRF7 and TLR9 mRNA in PBMCs were significantly higher in the patients with CA than in the controls （both P < 0.01）. Conclusion There is a significant increase in the expression of IRF7 and TLR9 in the PBMCs of patients with CA.

Key words: Monocytes