Chinese Journal of Dermatology ›› 2011, Vol. 44 ›› Issue (7): 517-518.

• Research reports • Previous Articles     Next Articles

Expression of Spa-1 and Ki-67 in tissues of extramammary Paget′s disease (EMPD)

  

  • Received:2010-09-19 Revised:2010-11-26 Online:2011-07-15 Published:2011-07-12

Abstract:

Objective To investigate the potential role of Spa-1 in the development and metastasis of EMPD. Methods Tissue specimens were resected from 17 patients with primary EMPD, 12 patients with invasive EMPD and 9 normal human controls. Immunohistochemistry was performed to measure the expression of Spa-1 and Ki-67. Results Positive staining was observed for Spa-1 in cytoplasm, and for Ki-67 in cell nuclei. Spa-1 and Ki-67 were weakly expressed in the basal layer of normal skin. The expression of Spa-1 and Ki-67 in EMPD tissue were statistically higher than those in the normal control tissue(both P < 0.01). Increased expression of Spa-1 was noted in invasive EMPD tissue compared with in situ EMPD tissue. The expression of Spa-1 was positively correlated with that of Ki-67 in the tissue of EMPD. Conclusion Spa-1 may play a certain role in the initiation and progression of EMPD.

Key words: Ki-67