过氧化物酶体增殖物激活受体在寻常性银屑病患者表皮中的表达

Abstract

Abstract:

Objective To investigate the expression of peroxisome proliferator-activated receptors （PPARs） in epidermal keratinocytes of patients with psoriasis vulgaris and its significance. Methods Immunohistochemical method was used to examine the expression of PPARα, β/δ and γ in tissue specimens from the normal skin of 5 human controls, lesional and normal skin adjacent to the lesions of 17 patients with psoriasis vulgaris. A semi-quantitative analysis was carried out by image analyzer. Results Different levels of expression of the three PPAR isotypes were observed in the nuclei of epidermal keratinocytes of normal human controls. The expression intensity of PPAR α, β/δ and γ was statistically higher in the epidermis of adjacent normal skin than that in psoriatic lesions （all P < 0.01） and normal control skin （all P < 0.01）. Conclusions The decreased expression of PPARα may be associated with the overproliferation and parakeratosis of epidermal keratinocytes in psoriatic lesions, and PPAR β/δ and γ may display a synergistic effect on the maintenance of homeostatic proliferation and differentiation of epidermal cells.

Key words: peroxisome proliferators activated receptor

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Expression of peroxisome proliferator-activated receptors in the epidermis of skin from patients with psoriasis vulgaris

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