Abstract: 【Abstract】 Objective To investigate clinical and dermoscopic manifestations of nail damage secondary to hand, foot and mouth disease. Methods Clinical data were collected from 12 patients with nail damage secondary to hand, foot and mouth disease in Department of Dermatology, Shandong Provincial Hospital from June to November 2015, and characteristics of nail damage were analyzed. Results The clinical manifestations of nail damage following hand, foot and mouth disease included dryness of periungual skin （12 cases）, nail plate cavities （11 cases）, nail fractures （11cases） and Beau′s lines （4 cases）. Dermoscopy showed nail discoloration （12 cases）, nail delamination （12 cases）, horizontal streaks （10 cases）, longitudinal streaks （8 cases）, brown background of the nail matrix （11 cases）, telangiectasia（7 cases）, periungual desquamation （12 cases） and red background （10 cases）. Conclusion The clinical manifestations of nail damage following hand, foot and mouth disease are mainly dryness of periungual skin, nail plate cavities and fractures, and its dermoscopic manifestations include nail discoloration, delamination, horizontal and longitudinal streaks, brown background of the nail matrix, telangiectasia, periungual desquamation and red background.

Key words: Hand, foot and mouth disease, Nail diseases, Dermoscopy