Chinese Journal of Dermatology

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Expression and significance of suppressor of cytokine signaling-1 and protein inhibitor of activated STAT-1 in condyloma acuminatum

TAO Xiao-hua1, MENG Qun2, PAN Wei-li1, DONG Yu-e1, LUO Jing1, CHENG Hao3   

  1. Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China
  • Received:2006-07-31 Online:2007-05-15 Published:2007-05-15

Abstract: Objective To explore the expression of suppressor of cytokine signaling-1(SOCS1) and protein inhibitor of activated STAT-1(PIAS1)in keratinocytes of condyloma acuminatum(CA) lesions and its significance.Methods SP immunohistochemistry technique was used to detect the expres-sion and distribution of SOCS1 and PIAS1 in lesions from 40 cases of CA and 20 cases of cervical cancer, and in skin(foreskins)of 20 normal controls.Results In CA lesions,SOCS1 and PIAS1 were stained brown-yellow in the cytoplasm of keratinocytes,and positive cells were mainly distributed in the prickle layer. In cervical cancer,they were also stained brown-yellow and diffusely distributed in the cytoplasm of carcino-ma cells.In normal skin,SOCS1 and PIAS1 weakly expressed in the cytoplasm of keratinocytes in basal layer, and were stained pale yellow.The positive rates of both SOCS1 and PIAS1 were significantly higher in CA lesions than in normal skin(85% vs 30%,χ2=18.15,P<0.01;80% vs 35%,χ2=11.87,P<0.01). Although the positive rates of SOCS1(90%)and PIAS1(85%)in cervical cancer were higher than those in CA,no significant difference was found between them(both P>0.05).There was no significant corre-lation between the expression of SOCS1 and PIAS1 in CA lesions(rs=0.14,P>0.05).Conclusion SOCS1 and PIAS1 may play a role in the overproliferation and malignant transformation of keratinocytes in CA lesions.

Key words: Condylomata acuminata, SOCSI, PIASI