Abstract:

Man Maoqiang, Se Kyoo Jeong, Byeong Deog Park, Peter M Elias Department of Dermatology, San Francisco Veterans Affairs Medical Center, University of California San Francisco, School of Medicine, and Northern California Institute for Research and Education, San Francisco, CA 94121, USA （Man MQ, Elias PM）; Research Division, NeoPharm Co., Ltd., Daejeon, Korea （Jeong SK, Park BD） Corresponding author: Man Maoqiang, Email: mqman@hotmail.com 【Abstract】 Sensitive skin is a skin condition featured by high sensitivity and low tolerance in response to external and internal stimuli. The prevalence of sensitive skin varies with age, gender, body sites, as well as race. The quality of life is substantially reduced in subjects with sensitive skin. Due to uncertainty of etiology, it has been a challenge to effectively manage sensitive skin. Recent studies have demonstrated pathogenic roles of epidermal permeability barrier and transient receptor potential vanilloid 1 （TRPV1） in the development of sensitive skin. Therefore, improvement in epidermal permeability barrier function and utilization of TRPV1 inhibitors may be valuable approaches to the management of sensitive skin.