Abstract:

Li Mingjing, Cao Jingjiang, Chen Hongxiang Department of Dermatology, The Second College of Clinical Medical Science, Three Gorges University, Yichang 443002, China （Li MJ, Cao JJ）; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China （Chen HX） Corresponding author: Chen Hongxiang, Email: hongxiangchen@hotmail.com 【Abstract】 Topical photodynamic therapy （PDT）, a highly effective, safe and non-invasive therapeutic method, exerts good therapeutic effects on various diseases in dermatology, such as actinic keratosis, condyloma acuminatum, acne，and so on. The major drawback of PDT is pain during the treatment. Some patients have to interrupt or terminate the treatment because of pain intolerance. Some progress has been made in the management of PDT-related pain. It has been revealed that multiple factors are associated with PDT-related pain, including individual factors, lesion characteristics, therapeutic parameters （such as light sources, photosensitizers）. Many methods can be used to manage PDT-related pain, including local cooling, oral analgesics, two-step irradiance protocol, topical anesthesia, injection anesthesia, inhalation anesthesia, transcutaneous electric nerve stimulation, hypnosis.