Abstract: Objective To investigate the significance of B7-CD28/CTLA-4 (CD152),co-stimulatory molecules of T lymphocytes,in the onset,development and prognosis of genital congdyloma acuminatum (CA) in females.Methods Flow cytometry was utilized to detect the expression levels of CD80/CD86 in peripheral blood lymphocytes and of CD28/CD152 (CTLA-4) in CD4⁺/CD8⁺ T lymphocytes from 30 CA patients (17 primary CA,13 recurrent CA,15 at recovery stage of CA) and 15 healthy volunteers as controls.Results No significant difference was found for the frequencies of CD80⁺,CD86⁺,CD4⁺/CD28⁺ and CD8⁺/CD28⁺ lymphocytes between the primary or recurrent group and the control group.The frequencies of CD8⁺/CD28⁺,CD4⁺/CD28⁺ and CD80⁺ lymphocytes were significantly higher in the recovery group than those in the recurrent group (P<0.05).The frequencies of CD4⁺/CD152⁺ and CD8⁺/CD152⁺ cells were significantly lower in the primary group than those in the recurrent group[(10.01±1.62)% vs (14.85±2.38)%,(9.09±1.20)% vs (14.91±1.87)%,both P<0.05],but significantly higher than those in the recovery[(10.01±1.62)% vs (5.30±0.43)%,(9.09±1.20)% vs (4.95±0.63)%,both P<0.05]and control groups[(10.01±1.62)% vs (1.75±0.10)%,(9.09±1.20)% vs (3.92±0.53)%,both P<0.05],and no significant difference of those cells was found between the control and recovery group (P>0.05).Conclusions There is an abnormal expression of co-stimulatory molecules B7-CD28/CTLA-4 (CD152) in periphoral blood lymphocytes,CD4⁺ and CD8⁺ T lymphocytes in female patients with genital CA,and the expression abnormaility is closely linked with different disease stages of CA.

Key words: Condylomata acuminata, Papillomavirus,human, T-lymphocytes, Antigens,CD28, Antigens,CD152, Antigens,CD80, Antigens,CD86