Abstract: Oxiconazole is a broad spectrum antimycotic drug. In vitro test, it showed marked mycostatic action on Trichophyton rubrum, Epidermophyton floccosum, Candida albicans, Cryptococcus neoformans, Sporothrix, etc. The therapeutic effect of 1% oxiconazole cream in comparison with 1% econazole cream was observed in a double-blind study.