Abstract: Objective To report a case of genital aspergillosis.Methods The clinical data,results of fungal examination and of computed tomography (CT) of chest were analyzed for this patient.Results A 33-year-old male patient with acute myelogenous leukemia underwent allogeneic hematopoietic stern cell transplant after relief induced by chemotherapy.Seven days after the transplant,he developed a persistent fever ranging between 38℃and 38.5℃,which did not respond to daily treatment with multiple antibiotics. Meanwhile,several eruptions appeared on the genitals.Physical examination revealed multiple round, well-circumscribed,edematous and erythematous lesions measuring 0.2～1cm in diameter with black eschar in their center on the scrotum and glans.Erosion and necrosis were also seen on the coronary sulcus.Aspergillus flavus was isolated from exudation and crust of the lesions.The infection was successfully treated by intravenous itraconazole and topical iodine solution for 33 days.One hundred and thirty-seven days after the transplant,CT of the chest revealed a cavitary lesion on the right upper lung,measuring 16.6 mm×15.2 mm, strongly suggesting a chronic fungal infection.Conclusion A case of genital aspergillosis,likely to be caused by hematogenous spread from pulmonary lesion following allogeneic hematopoietic stem cell transplantation,is reported here.

Key words: Aspergillosis, Aspergillus flavus, Leukemia, myeloid, Hematopoietic stem cell trans-plantation