Abstract: Objective To investigate the abnormal expression of signal transducers and activators of transcription 1(Stat 1)and Src-homology 2 domain phosphatasel(SHP-1)in JAK/STAT route of condyloma acuminatum(CA)and its significance.Methods HPV6/11 related CA was diagnosed by in situ hybridization;the expression and distribution of Stat 1 and SHP-lwere examined by SP immunohistochemistry in 40 specimens from CA patients positive for HPV 6/11 and 20 normal skin specimens (foreskins).Results The expression of both Stat 1 and SHP-1 was significantly higher(both P<0.01) in CA lesions than that in normal epithelium.The Stat 1-and SHP-1-positive cells were mainly distributed in prickle layer of HPV 6/11 related CA lesions.The positive signal of Stat 1 was located in the cytoplasm or nuclei,and that of SHP-1 was mainly distributed in the cytoplasm.There was a significant correlation(P<0.01)between the expression of Star 1 and that of SHP-1 in HPV 6/11-related CA lesions.Conclusion The expression of Stat 1 and SHP-1 is increased in HPV6/11 positive CA lesions,which suggests that HPV6/11 may play a role in the over-proliferation of keratinocytes through JAK/STAT route.

Key words: Condylomata acuminata, Papillomavirus, human, Protein-tyrosine-phosphatase, Signal transducers and activators of transcriptionl