Chinese Journal of Dermatology ›› 2026, e20230768.doi: 10.35541/cjd.20230768

• Reviews •     Next Articles

Research and application of skin substitutes in chronic wounds

Zhang Ying1, Wang Wenhui1, Zhang Chunlei1, Tie Lu2, Zhang Long3   

  1. 1Department of Dermatology, Peking University Third Hospital, Beijing 100191, China; 2Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China; 3Wound Healing Center, Peking University Third Hospital, Beijing 100191, China
  • Received:2023-12-27 Revised:2025-03-13 Online:2026-02-09 Published:2026-05-25
  • Contact: Zhang Long E-mail:Longzh2000@163.com
  • Supported by:
    Beijing Municipal Natural Science Foundation

Abstract: 【Abstract】 With the aging of the population and changes in lifestyle, the spectrum of wound diseases is gradually changing, and the incidence of chronic wounds is gradually increasing. There exist many challenges in the treatment of chronic wounds and an urgent need for more effective treatments. In the field of chronic wound treatment, skin substitutes based on bioengineering technology have emerged as a research hotspot. This review summarizes recent research and application progress of epidermal, dermal and composite skin substitutes in chronic wounds.

Key words: Skin, artificial, Skin substitutes, Chronic wounds, 3D bioprinting