Abstract: Liang Jinning, Jin Waishu, Shao Juan, Qu Yan, Xia Xiujuan Department of Dermatology, Yantai Yuhuangding Hospital, Yantai 264000, Shandong, China Corresponding author: Xia Xiujuan, Email: xiaxiujuan@medmail.com.cn 【Abstract】 Objective To evaluate the efficacy and safety of near-infrared light combined with tacrolimus 0.1% ointment in the treatment of facial glucocorticoid-dependent dermatitis. Methods A total of 68 patients with facial glucocorticoid-dependent dermatitis were enrolled from Department of Dermatology of Yantai Yuhuangding Hospital between December 2014 and December 2015, and randomly and equally divided into treatment group and combination group by a random number table. The treatment group was treated topically with tacrolimus ointment twice a day for 4 weeks. Besides the treatment with tacrolimus ointment, the combination group was irradiated with near-infrared light once a week for 4 sessions. After 4-week treatment, improvement in clinical manifestations such as itching and burning sensation was evaluated, so was the therapeutic effect. Results The combination group showed significantly higher response rate （85.3% ［29/34］） compared with the treatment group （61.8% ［21/34］, χ2 = 4.84, P < 0.05）. Additionally, response rates for itching and burning sensation, erythema, scales and papules were all significantly higher in the combination group than in the treatment group （χ2 = 4.84, 6.35, 8.42 and 5.52, respectively, all P < 0.05）. Conclusion Near-infrared light combined with tacrolimus ointment is effective and safe for the treatment of facial glucocorticoid-dependent dermatitis.