Abstract: Li Yan, Xu Wei, Yang Baoqi, Tian Hongqing, Duan Yiqun, Wang Xiangdong, Lu Xueyan, Ye Zhenzhen, Ju Mei, Gu Heng, Zhao Jianping, Chen Xing, Wang Yuhan, Liu Lingling, Li Linfeng Department of Dermatology and Venereology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China （Li Y, Xu W, Li LF）; Department of Dermatology, Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China （Yang BQ, Tian HQ）; Department of Dermatology, Wuhan No. 1 Hospital, Wuhan 430022, China （Duan YQ, Wang XD）; Department of Dermatology, Peking University Third Hospital, Beijing 100191, China （Lu XY, Ye ZZ）; Department of Physical Therapy, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China （Ju M, Gu H）; Department of Dermatology, Chinese People′s Armed Police Force, Zhejiang Corps Hospital, Jiaxing 314000, Zhejiang, China （Zhao JP, Chen X）; Department of Dermatology, Peking University First Hospital, Beijing 100034, China （Wang YH, Liu LL） Corresponding authors: Li Linfeng, Email: zoonli@sina.com; Xu Wei, Email: 2403649155@qq.com 【Abstract】 Objective To evaluate the efficacy and safety of Qingpeng ointment for the treatment of localized eczema in children. Methods A multicenter, randomized, open?labeled, tacrolimus 0.03% ointment?controlled clinical trial was conducted. A total of 442 children with localized eczema were enrolled into this study, and divided into 2 groups to topically apply Qingpeng ointment （Qingpeng group） and tacrolimus 0.03% ointment （tacrolimus group） respectively twice a day for 2 weeks. The children were followed up before the treatment and 1, 2 weeks after the treatment, and the efficacy and safety were evaluated at the same time. Results Clinical data from 426 children were included in the efficacy analysis. At 1, 2 weeks after the treatment, there were no significant differences in the response rate between the Qingpeng group and tacrolimus group （1 week after the treatment: 78.92% vs. 81.77%, χ2 = 0.545, P = 0.460; 2 weeks after the treatment: 98.65% vs. 97.54%, χ2 = 0.721, P = 0.396）. However, the pruritus scores at 1, 2 weeks after the treatment were both significantly lower in the Qingpeng group than in the tacrolimus group （1 week: F = 14.001, P = 0.000; 2 weeks: F = 11.252, P = 0.001）. At 1 week after the treatment, the incidence rate of adverse reactions was significantly lower in the Qingpeng group than in the tacrolimus group （P < 0.05）. Mild itching, burning sensation and other local irritant sensations were the most common adverse reactions. Conclusion Qingpeng ointment is safe and effective for the treatment of localized eczema in children with good tolerability.