Abstract: Chen Mincong, Wang Jianqin, Fang Ruihua, Jia Shuqing, Mo You, Mo Jinxue Department of Dermatology, Hospital of South China Agricultural University, Guangzhou 510642, China （Chen MC）; Institute of Dermatology, Guangzhou Medical University, Guangzhou Institute of Dermatology, Guangzhou 510095, China （Wang JQ）; Department of Dermatology, Guangzhou First People′s Hospital, Affiliated to Guangzhou Medical University, Guangzhou 510180, China （Fang RH, Mo Y）; Department of Dermatology, Guangzhou Nansha Central Hospital, Guangzhou First People's Hospital, Affiliated to Guangzhou Medical University, Guangzhou 511457, China （Jia SQ, Mo JX） Corresponding author: Wang Jianqin, Email: jianqinwang@foxmail.com 【Abstract】 Objective To determine the of Caspase 8 and phospho?Akt （p?Akt） in condyloma acuminatum （CA） lesions, and to evaluate their significance. Methods Skin lesion samples were collected from 30 patients with CA, cancer tissue samples from 20 with cervical cancer, and normal skin samples from 20 healthy controls. All the samples were subjected to paraffin embedding. An immunohistochemical study was conducted to determine the and distribution of Caspase 8 and p?Akt in the above samples. Results The rate of Caspase 8 was significantly lower in CA lesions （23.33%） than in normal skin samples （90%, P < 0.01） and cervical cancer lesions （80%, P < 0.001）. Moreover, the rate of p?Akt in CA lesions （93.33%） was significantly higher than that in the normal skin samples （90%, P < 0.001）, but lower than that in the cervical cancer lesions （95%, P < 0.001）. No significant correlations were observed between the of Caspase 8 and p?Akt in either CA lesions or normal skin samples. However, the of Caspase 8 was positively correlated with the of p?Akt in cervical cancer lesions （r = 0.369, P < 0.05）. Conclusion Both suppressed apoptosis initiation of Caspase 8 and anti?apoptotic effect of p?Akt may be involved in the occurrence and development of CA.