Abstract: Yang Min, Liu Wan, Yu Jie, Bao Yingqiu, Fu Yu, Gao Xiaoman, Chang Jianmin Department of Dermatology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China （Yang M, Liu W, Bao YQ, Fu Y, Gao XM, Chang JM）; Department of Gynaecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China （Yu J） Corresponding author: Chang Jianmin, Email: changjm0417@126.com 【Abstract】 Objective To investigate clinical features and therapeutic protocols of vulvovaginal?gingival syndrome （VVGS）. Methods Clinical data were collected from 11 female patients with VVGS and analyzed. Results Among the 11 patients, the mean and median ages at a definite diagnosis of VVGS were both 46 years, and the average disease duration was 4 years. Painful erosive erythema was found on the vaginal vestibule in 7 patients, on the gingiva in 10, as well as on the bilateral buccal mucosa in 5. Additionally, 8 and 4 patients reported dyspareunia and vaginal hemorrhage, respectively. Seven patients were treated with low?dose oral methylprednisolone combined with hydroxychloroquine or colchicine, and the other 4 were treated with oral hydroxychloroquine alone. Furthermore, all of the 11 patients applied topical tacrolimus 0.1% ointment. Finally, 8 patients were cured or markedly improved. No obvious adverse reactions were observed in any of the patients. Conclusions VVGS mostly occurs in middle?aged women, with the vaginal vestibule and gingiva as predilection sites of painful erythema and dyspareunia as common symptoms. Patients have good responses to methylprednisolone combined with hydroxychloroquine, and hydroxychloroquine alone also shows good efficacy in patients with mild VVGS. Tacrolimus 0.1% ointment can be one of drugs for topical maintenance treatment of VVGS.