Abstract:

Wang Qian, Liu Yuping, Shuai Ping, Liu Wei, Zhang Lixia, Duan Xiling Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences and Sichuan Provincial People′s Hospital, Chengdu 610072, China （Wang Q, Liu W, Zhang LX, Duan XL）; Center of Health Management, Sichuan Academy of Medical Sciences and Sichuan Provincial People′s Hospital, Chengdu 610072, China （Liu YP, Shuai P） Corresponding authors: Duan Xiling, Email: uanxilingd@hotmail.com; Liu Yuping, Email: liuyuping555@126.com 【Abstract】 Objective To explore the relationship of neutrophil-to-lymphocyte ratio （NLR） and platelet-to-lymphocyte ratio （PLR） with gastrointestinal bleeding in adult patients with Henoch-Sch?nlein purpura （HSP）. Methods Laboratory data including routine blood test results, C-reactive protein （CRP） levels and erythrocyte sedimentation rate （ESR） were collected from 115 adult patients with HSP and 100 healthy controls, and retrospectively analyzed. NLR and PLR were calculated and compared. Logistic regression analysis was used to determine variables associated with gastrointestinal bleeding in adult patients with HSP, and the receiver operating characteristic （ROC） curve was drawn to estimate the predictive efficacy of these variables. Results NLR and PLR were both significantly higher in adult patients with HSP than in healthy controls （both P < 0.05）, and NLR, PLR and CRP levels were all significantly higher in adult HSP patients with gastrointestinal bleeding than in those without （all P < 0.05）. Logistic regression analysis showed that NLR was an independent risk factor for gastrointestinal bleeding in adult HSP patients （P < 0.05）. The ROC curve revealed that the optimal cut-off point of NLR for predicting gastrointestinal bleeding was 3.24 in adult patients with HSP, with the sensitivity and specificity being 85.1% and 71.3% respectively. Conclusions Both NLR and PLR evidently increase in adult patients with HSP, especially in those with gastrointestinal bleeding. NLR is a potential predictor for gastrointestinal bleeding in adult patients with HSP.