Abstract:

Liu Xiaochun, Yao Xu Department of Allergy and Rheumatology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China Corresponding author: Yao Xu, Email: dryao_xu@126.com 【Abstract】 Transcutaneous immunization （TCI） is a novel immunotherapy approach that induces systemic immune responses via topical application of antigens and adjuvants onto the skin. It is a safe and effective method, and is expected to serve as an attractive alternative to traditional vaccination. TCI induces immune responses in different directions, but the exact mechanism of skin immune tolerance is still unclear. Most studies on TCI are based on animal models. However, there are structural differences between animal skin and human skin, so more researches are needed to achieve the translation of TCI from bench to bedside. Not all vaccines are suitable for cutaneous inoculation, so vaccines for TCI should be evaluated for their safety and efficacy. Various reformed vaccine delivery systems are needed to be further explored in related diseases.