Abstract:

Li Li, Chen Xu, Gu Heng Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China Corresponding author: Gu Heng, Email: guheng@aliyun.com 【Abstract】 Ultraviolet （UV） is a kind of important environmental factor that can cause dermatitis, photoaging and skin cancerization. The UV-induced production of inflammatory factors by epidermal keratinocytes has been deemed an important molecular event in occurrence of the above diseases. Various receptors, intracellular signal transduction-related regulatory molecules and nuclear transcription factors are involved in UV-induced inflammatory responses in keratinocytes, which mainly include epidermal growth factor receptor, aryl hydrocarbon receptor, peroxisome proliferator-activated receptor, protein kinase C family, protein kinase B, mitogen-activated protein kinase family, nuclear factor-κB and transcription factor activator protein-1, etc, and constitute a complex inflammatory signal transduction network.