Abstract:

Zhu Xiaoxia*, Zhou Qiang, Cheng Hao, Zhu Hongming. *Ningbo First Hospital, Ningbo 315010, Zhejiang, China Corresponding author: Cheng Hao, Email: hz_chenghao@126.com 【Abstract】 Objective To investigate the possible roles of Langerhans cells （LCs） and plasmacytoid dendritic cells （pDCs）in the pathogenesis of condyloma acuminatum （CA）. Methods Tissue specimens were obtained from the lesions of 23 patients with CA and from perilesional normal skin of 13 of the 23 patients. The expressions and distribution of CD1a, CD2AP and CD123 were analyzed using the streptavidin-peroxidase （SP） immunohistochemical method. Statistical analysis was carried out to compare the density and percentage of CD1a+ LCs, CD2AP+ pDCs and CD123+ pDCs between lesional skin and perilesional normal skin. Results Most CD1a+ LCs were observed in the prickle cell layer of the epidermis, and a few in the papillary layer of the dermis. There was no significant difference in the density or percentage of CD1a+ LCs in the epidermis or dermis between the lesional and perilesional skin specimens（all P > 0.05）. CD2AP+ pDCs and CD123+ pDCs were distributed mainly in the papillary layer of the dermis, and their density and percentage were significantly higher in the lesional than in the perilesional skin specimens （all P < 0.05）. Conclusion Human papillomavirus infection may affect the quantity of pDCs but not LCs in local mucous membranes.