Chinese Journal of Dermatology ›› 2014, Vol. 47 ›› Issue (4): 247-250.

• Original articles • Previous Articles     Next Articles

A case of S100-positive atypical juvenile xanthogranuloma: a longitudinal observation and review of the literature

  

  • Received:2013-07-04 Revised:2014-01-16 Online:2014-04-15 Published:2014-04-01

Abstract: Wang Yanhong, Shen Hong, Xu Aie. Department of Dermatology, Third People′s Hospital of Hangzhou, Hangzhou 310009, China Corresponding anthor: Shen Hong, Email: shenhongsh@medmail.com.cn 【Abstract】 A 3-year-old boy presented with a 3-month history of brown-yellow papules scattered on the trunk. The first skin biopsy showed a dermal infiltrate of many mononuclear histiocytes, eosinophilic granulocytes and a small number of lymphocytes. Immunohistochemical examination of the lesions demonstrated positive reactions with anti-CD68, -S100 and -CD1a (partial) antibodies. After the biopsy, the skin lesions gradually turned dark and partially regressed leaving hyperpigmentation, but new lesions continuously appeared. Four months later, a second biopsy was performed, and showed a dermal infiltrate of histiocytes with eosinophilic granulocytes and a few multinucleated giant cells. Immunohistochemistry showed that the histiocytes stained positive for CD68, but negative for S100 and CD1a. Based on the above findings, the patient was diagnosed with juvenile xanthogranuloma.

Key words: Xanthogranuloma, juvenile, S100 proteins, Antigens, CD1