Abstract: Zhang Rongrong, Zhu Xiaohong. Department of Pathology, Wuxi No.2 People′s Hospital, Wuxi 214002, China Corresponding author: Zhu Xiaohong, Email: Zrr3161_cn@sina.com 【Abstract】 Objective To describe the clinicopathologic features of two cases of mucoepidermoid carcinoma of the skin. Methods Two cases of mucoepidermoid carcinoma of the skin were analyzed histopathologically using hematoxylin and eosin （HE） staining, alcian blue-periodic acid Schiff （AB-PAS） staining and immunohistochemical staining. Relavant literature was reviewed. Results Histopathological examination showed that the tumor was subcutaneously located in both cases, with epidermoid cells and intermediate cells arranged in sheets or nests, as well as different sizes of glandular structures lined by mucinous columnar epithelium in some areas. Both tumors had a relatively clear boundary with peripheral invasive growth and no obvious capsules. Immunohistochemical examination showed positive staining for carcinoembryonic antigen （CEA）, high and low molecular weight cytokeratin （CK（H） and CK（L））. The cytoplasm of mucous cells was stained blue with, and mucus was visualized after, AB-PAS staining. Conclusions Primary mucoepidermoid carcinoma of the skin is a kind of malignant tumor arising from skin appendages, whose diagnosis depends on histological and immunohistochemical examination. 【Key words】 Carcinoma, mucoepidermoid; Case reports ［publication type］

Key words: Carcinoma, mucoepidermoid, Case reports ［publication type］