Abstract: YUAN Jian-guo, CAI Zai-sheng, LIU Rui, PENG Jing, CAO Yu-chun, ZHANG Yong*. *Department of Dermatology, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Corresponding author: ZHANG Yong, Email: zhangyongtj@gmail.com 【Abstract】 Objective To assess the clinical and pathological feature of patients with livedo vasculitis. Methods Clinical data were collected from 47 patients with livedo vasculitis, and retrospectively analyzed. All the patients were classified into three groups according to treatment strategy: anticoagulation group, anticoagulation + corticosteroids group, and anticoagulation + sulfasalazine group. Results Clinically, livedo vasculitis usually began as petechia or ecchymosis, edema with distending pain, followed by spotty necrosis which subsequently evolved into vermiculated ulcers and, finally, atrophie blanche. Pathological features included fibrinoid degeneration of and thrombus formation in small vessel walls within the superficial or deep dermis, as well as a sparse lymphocytic infiltrate around the injured vessels. The average time to onset of action of administrated drugs was （9.14 ± 3.48）, （5.62 ± 1.04） and （8.23 ± 2.68） days, and time to remission was （2.57 ± 1.41）, （4.06 ± 1.51） and （5.64 ± 1.32） months, in the anticoagulation group, anticoagulation + corticosteroids group and anticoagulation + sulfasalazine group, respectively. Conclusion Anticoagulation in combination with anti-inflammatory therapy appears to have a more rapid onset of action in the treatment of livedo vasculitis with a reduced recurrence rate compared with anticoagulation therapy alone. 【Key words】 Livedo vasculitis; Anticoagulants; Anti-inflammatory drugs; Pathology