Abstract: QIN Xiao-ming, JI Yi-ru, WU Li. Department of Dermatology, Second Affiliated Hospital of Wannan Medical College, Wuhu 241000, Anhui, China Corresponding author: QIN Xiao-ming, Email: qxming_118@163.com 【Abstract】 A 48-year-old female presented with a one-week history of painful and enlarged lymph nodes in the left neck. One-week systemic treatment with antibiotics resulted in no obvious improvement. Skin examination revealed palpable lymph nodes between the left lateral cervical papillae and clavicle, which appeared as a string of beads with a little mobility and obvious tenderness. The largest diameter of enlarged lymph nodes was about 2 cm. No enlarged lymph nodes were palpable in the other body sites. Histopathologically, histiocytes of various shapes, immunoblasts and plasmacytoid monocytes markedly proliferated with different degrees of karyorrhexis. Immunohistochemistry revealed that the lesions were positive for CD3, CD8, CD68, mouse macrophage inflammatory protein, and CD20. A diagnosis of histiocytic necrotizing lymphadenitis was made.

Key words: Necrosis