Abstract: LI Yong*, MENG Hui-min, WANG Ting-ting, XIAN Yan, TU Ying, HE Li, LI Li. *Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China Corresponding author: LI Li, Email: lilihx_scu@scu.edu.cn 【Abstract】 Objective To evaluate the effectiveness and safety of a sodium hyaluronate-containing dressing for skin wound healing after Q-switched laser therapy. Methods Sixty-six patients with facial pigmentary disorders were enrolled in this study. After treatment with Q-switched laser, the patients were randomly and equally divided into three groups to apply a sodium hyaluronate-containing dressing, a thermal spring water-containing facial mask and a distilled water-containing facial mask respectively. The dressing or facial masks were externally applied to the face for 15 minutes once immediately after the laser therapy, then, once every night for 14 consecutive days. Inflammatory responses, such as erythema, edema and burning sensation, were measured semi-quantitatively on day 1, 3, 7 and 14 separately after the laser therapy. The time for skin wound healing and degree of patients′ satisfaction were compared among these groups by chi-square test and rank sum test, respectively. Results The sodium hyaluronate-containing dressing and thermal spring water-containg facial mask were superior to the distilled water-containing facial mask in the improvement of erythema, edema and burning sensation after the laser therapy（all P < 0.05）. Compared with the patients applying the thermal spring water-containg facial mask and those applying the distilled water-containing facial mask, those applying the sodium hyaluronate-containing dressing felt better, with significantly increased skin cleanliness, humidity, smoothness, confort degree and overall satisfaction （all P < 0.05）. Conclusion The sodium hyaluronate-containing dressing is effective for improving acute inflammatory responses and increasing skin cleanliness, humidity and smoothness after laser therapy.