蒙古族寻常性银屑病与HLA-Cw及DRB1位点相关性研究

Abstract

Abstract:

【Abstract】 Objective To investigate the association of HLA-Cw and -DRB1 alleles with psoriasis vulgaris, and to provide a clue to the study into the etiology of psoriasis. Methods Venous blood samples were obtained from 81 patients with psoriasis vulgaris collected during 2006－2011 at the Department of Dermatology, First Affiliated Hospital of Inner Mongolia Medical College, as well as 100 age- and gender-matched healthy controls. Both the patients and controls are unrelated Mongolia in Inner Mongolia. PCR with sequence-specific primers （PCR-SSP） technique was used to genotype the HLA-Cw and DRB1 loci. Results The patients with psoriasis vulgaris showed a significantly higher frequency of HLA-Cw*06 （0.438 vs. 0.175, Pc < 0.01） and DRB1*07 （0.241 vs. 0.110, Pc < 0.012）, but a lower frequency of HLA-Cw*04 （0.031 vs. 0.150, Pc < 0.01） and DRB1*04 （0.093 vs. 0.235, Pc < 0.01） than the healthy controls did. Increased frequencies of HLA-Cw*06 and DRB1*07 alleles were observed in patients with an onset before 40 years of age and those without a family history, together with a decreased frequency of HLA-Cw*04 and DRB1*04 alleles, compared with the healthy controls （Pc < 0.05）. The frequency of HLA-Cw*06 allele was significantly higher in patients with a positive family history and patients with an onset of no younger than 40 years of age than in the healthy controls （both Pc ＜ 0.05）. Conclusions HLA-Cw*06 and -DRB1*07 alleles may be susceptibility determinants to psoriasis vulgaris, while HLA-Cw*04 and -DRB1*04 alleles may be protective factors against psoriasis vulgaris, in Mongolia from Inner Mongolia. HLA-DRB1*07 allele may be a susceptibility gene for psoriasis, while HLA-Cw*04 and -DRB1*04 alleles may be protective factors against psoriasis, in patients with an onset before 40 years of age.

Key words: Association

References

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Association of HLA-Cw and -DRB1 alleles with psoriasis vulgaris in Mongolian population

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