Chinese Journal of Dermatology ›› 2011, Vol. 44 ›› Issue (7): 523-525.

• Research reports • Previous Articles     Next Articles

Expression of erbB4 and PTEN in cutaneous squamous cell carcinoma tissue

  

  • Received:2010-09-08 Revised:2010-10-12 Online:2011-07-15 Published:2011-07-12

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Abstract:

Objective To investigate the expression of erbB4 and PTEN in cutaneous squamous cell carcinoma （SCC） tissue and their significance. Methods Immunohistochemical Elivision method was used to measure the protein expression of erbB4 and PTEN in tissue specimens from 52 patients with SCC （11 cases with and 41 cases without lymph node metastasis） and 10 normal human controls. Results The positivity rate of erbB4 was significantly higher in the patients with SCC than in the normal human controls （75% vs. 10%, χ2 = 12.77, P < 0.01）, and in the patients with lymph node metastasis than in those without （100% vs. 68.29%, P < 0.05）. Significant differences were also observed in the expression rate of PTEN between the patients with SCC and the normal controls （48.08% vs. 100%, χ2 = 9.20, P < 0.01）, between the patients with well-differentiated SCC and those with poorly differentiated SCC （78.57% vs. 36.84%, P < 0.05）, and between the patients with lymph node metastasis and those without （9.09% vs. 58.54%, P < 0.01）. The expression of erbB4 was negatively correlated with that of PTEN （r = -0.42, P < 0.01）. Conclusion The disturbance in mutual regulation between erbB4 and PTEN seems to be involved in the initiation, progression and metastasis of SCC.