尖锐湿疣组织内血管内皮生长因子和转化生长因子-α表达

Abstract

Abstract:

Objective To investigate the role of vascular endothelial growth factor （VEGF） and transforming growth factor-α （TGF-α） in the angiogenesis of condyloma acuminatum （CA）. Methods Tissue specimens were obtained from the lesions of 30 patients with CA and foreskin of 15 normal human controls. Reverse transcription （RT）-PCR and immunohistochemical method were utilized to measure the protein and mRNA expressions of VEGF and TGF-α in the specimens. Microvessel density（MVD） was determined by staining with anti-CD34 polyclonal antibodies. Results A statistical elevation was observed in the expression of VEGF and TGF-α mRNA as well as MVD in CA specimens compared with the normal control specimens （P < 0.001, 0.001, 0.01）. The expressions of VEGF and TGF-α protein were observed in 90% and 86.7% of the CA specimens, and in 40% and 26.7% of the control specimens （both P < 0.01）. MVD was positively correlated with the expression of VEGF and TGF-α protein in CA tissues （both P < 0.01）. Conclusion The overexpression of VEGF and TGF-α in CA tissue may accelerate angiogenesis in, and participate in the development and progression of, CA.

Key words: condyloma acuminatum

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Expressions of vascular endothelial growth factor and tranforming growth factor-α in condyloma acuminatum tissues

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