Abstract:

Objective To investigate the significance of T-bet and GATA-3 in the pathogenesis of pityriasis rosea. Methods SYBR Green I real-time fluorescence quantitative PCR was performed to detect the expressions of T-bet and GATA-3 mRNA in peripheral blood mononuclear cells （PBMCs） from 17 patients with pityriasis rosea and 20 normal human controls. Results The average delta Ct value of T-bet mRNA and GATA-3 mRNA was 3.33 ± 0.94 and 5.22 ± 0.69 respectively in the patients, 4.31 ± 1.11 and 4.36 ± 1.02 respectively in the controls. There was a higher expression of T-bet mRNA but a lower expression of GATA-3 mRNA in the patients compared with the controls （both P < 0.05）. Conclusions Patients with pityriasis rosea show an increased ratio of T-bet to GATA3 expression and predominant expression of Th1-type cytokines. Abnormal cellular immunity may play an important role in the pathogenesis of pityriasis rosea.