Chinese Journal of Dermatology ›› 2011, Vol. 44 ›› Issue (11): 803-804.
• Research reports • Previous Articles Next Articles
Received:
Revised:
Online:
Published:
Abstract:
Objective To investigate the protein expressions of PTEN and p-Akt in Kaposi′s sarcoma (KS) tissue and their significance in the development of KS. Methods The EnVision two-step method was used to detect the expressions of PTEN and p-Akt proteins in tissue specimens from the lesions of 17 patients with KS and from the normal skin of 17 normal human controls. Results PTEN and P-Akt were mainly expressed in the cytoplasm of cells. No significant difference was observed in the positivity rate of PTEN [76.5%(13/17) vs. 88.2%(15/17), P > 0.10] between the KS and control specimens. p-Akt was expressed in all (100%) of the 17 KS specimens, but in none of the control specimens. Conclusion The abnormal expression of PTEN protein may play a certain role in the development of KS.
Key words: Immunohistochemistry
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: http://www.pifukezazhi.com/EN/
http://www.pifukezazhi.com/EN/Y2011/V44/I11/803
Cited