Abstract:

Objective To assess the impact of intense pulsed light （IPL） on the dermatopathological manifestation in a Bama miniature pig model of steroid-induced dermatitis. Methods Five female Bama miniature pigs aged two months were selected. The white skin areas with white hair at both sides of the neck served as the target area. Halometasone （0.05%） cream was applied to the right target area twice daily for 60 days to establish a model of steroid-induced dermatitis. Then, 3 pigs were randomly selected and irradiated with IPL of 25 J/cm2 at the model area with an interval of 3 weeks for 9 weeks, the remaining 2 pigs receiving no treatment served as the natural recovery group. Finally, skin tissues were obtained from the left and right target areas and subjected to haematoxylin and eosin staining for the observation of histopathological changes. Results A significant increase was observed in the layer number of keratinocytes and thickness of dermal collagen fiber in the IPL-treated pigs compared with the pigs in natural recovery group（6.27 ± 1.26 vs. 2.98 ± 0.92, t = 3.27, P ＜ 0.01; 1.88 ± 0.19 mm vs. 0.84 ± 0.15 mm, t = 4.25, P ＜ 0.01）. Moreover, IPL irradiation resulted in the regression of telangiectasis in the dermis. Conclusion IPL may increase skin thickness, relieve flushing and improve skin elasticity efficiently.

Key words: dermatopathology