Chinese Journal of Dermatology ›› 2010, Vol. 43 ›› Issue (12): 871-872.

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Detection of peripheral blood regulatory T cells and serum interleukin-17 in patients with chronic idiopathic urticaria

  

  • Received:2010-04-08 Revised:2010-06-02 Online:2010-12-15 Published:2010-12-13

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Abstract:

[Abstract] Objective To explore the populations of circulating CD4+CD25+regulatory T cells and serum levels of IL-17 in patients with chronic idiopathic urticaria. Methods The populations of circulating CD4+CD25+regulatory T cells were detected with flow cytometric assay and the serum levels of IL-17 were measured by ELISA in 30 patients with chronic idiopathic urticaria and 30 normal controls. Results A significant decreased frequency of CD4+CD25+regulatory T cells was observed in patients with chronic idiopathic urticaria compared to normal controls（t =3.021，P<0.01）;While the serum levels of IL-17 were higher in patients with chronic idiopathic urticaria than that in normal controls（t =3.365，P<0.01）.Furthermore ,the serum levels of IL-17 were positively related to the disease score (r=0.6586, P <0.05). Conclusion Our data demonstrate that there is an imbalance between CD4+CD25+regulatory T cells and Th17 cells in the patients with chronic idiopathic urticaria, and that may play an important role in the pathogenesis of chronic idiopathic urticaria. Factors regulating apoptosis and homeostasis of CD4+CD25+regulatory T cells and Th17 cells are new therapeutic targets.