Abstract:

Objective To analyze the diagnosis and therapy of pemphigus and pemphigoid.Methods Clinical data of 648 patients of pemphigus or pemphigoid were retrospectively analyzed.Results The mean first-onset-age of pemphigus was smaller than pemphigoid(p<0.001).In 175 patients of pemphigus confirmed by direct immunoflorescence(DIF), IgG deposition were 100% positive,while C3 92.0％.In 223 patients of pemphigoid,the proportion of C3 positive was 99.1％. ①To patients of pemphigus,coincidence proportion of clinical diagnosis, pathology and DIF was 68.8%,while the proportion of the later two was 80.7%. ②To patients of pemphigoid, consistent rate of clinical diagnosis, pathology and DIF was 62.8%,while the proportion of the later two was 78.1%.The patients were mainly treated with corticosteroids in a dosage of 0.5～1.5 mg?kg-1?d-1(prednisone). Conclusion For cases of pemphigus and pemphigoid which can’t be confirmed by clinical features and pathology, DIF is an important diagnostic method.Doctors in community hospital with limited funds could mainly test IgG and C3 when the diagosis of pemphigus was doubtable.Similarly,they could mainly test C3 if they consider pemphigoid as first diagnosis. Corticosteroid is the chief way for controlling the two dieases,while intra venousimmunoglobulin(IVIG) could be added when necessary.

Key words: Pemphigus;Pemphigoid;DIF;Corticosteroid