Abstract:

Here four cases of folliculotropic mycosis fungoides are reported. Of these patients, one was a female and three were males with the age varying from 32 to 52 years. Three patients presented with multiple, densely distributed, irregularly shaped, dark red infiltrated plaques, nodules, tumors, follicular papules and acneiform lesions preferentially distributed on the head and neck, as well as patches and mildly infiltrated plaques, follicular papules and acneiform lesions on the trunk and extremities. One patient presented with follicular papules all over the body with the exception of head and face. Characteristic findings of histopathology included massive lymphoid cell infiltration, heteromorphism of some cells and migration of infiltrated cells into follicular epithelium. No typical epidermotropism was noticed. Two cases showed muciprotein deposition in follicular epithelium, which was positive for alcian blue staining. The infiltrates were predominated by CD4+ T lymphocytes. Folliculotropic mycosis fungoides is a refractory disease with poor response to conventional therapy of classical mycosis fungoides. Relapse is common in patients with partial remission.