Abstract:

[Abstract] Objective: To study the relationship between vulvar condylomata acuminata lesion and cervical HPV infection in female patients of Shanghai area. Methods: HPV DNA typing of 194 specimens from acuminata lesions and cervical cell collections was performed using hybridization and gene chip techniques. Results: HPV were detected in all 194 patients (100%). Among them, LR-HPV and HR-HPV infection was 74.2% (144/194) and 25.8% (50/194), respectively. LR-HPV infection was mainly characterized as a single HPV type (94.4%, 136/144) – either HPV6 or HPV11. In contrast, 86% (43/50) of HR-HPV infection were mixed with LR-HPV. Cervical cell examination showed that 85.6% (166/194) of patients were accompanied with HPV infection (LR = 61.4%, HR = 23.7%). In term of HPV type, the correlation between acuminata lesion and the cervix was 95.8%. The order of LR-HPV was HPV11>HPV6>HPV53 and that of HR-HPV was HPV16>HPV18>HPV52>HPV31 >HPV45 and HPV58. Conclusions: The infection rate of HR-HPV was high among female acuminata patients in Shanghai area and 1/4 of them were accompanied with HR-HPV infection of cervix. Therefore, dermatologists should pay attention to such infection in order to reduce the cervical cancer associated with HR-HPV infection.

Key words: Condyloma Acuminatum, Human papilloma virus