Abstract: Objective To analyze the features of cutaneous lesions and age of onset of tuberous sclerosis （TS）. Methods A total of 54 TS patients were recruited; their clinical data were analysed. Results The occurance of facial angiofibromas, periungual fibromas, hypomelanotic macules and shark macules was 72.5%, 26%, 70% and 48%, respectively, and the median age of onset of these lesions was 7, 14, 0.2 and 6 years, respectively, with a peak at 1-9, 10-19, < 1 and 1-9 years, respectively. Conclusions Cutaneous lesions are commonly seen in TS, and most of them develop early in life.