Abstract: Objective To explore the expression and significance of signal transducer and activator of transcription 3 （Stat 3）, glucose transporter protein 1 （GluT-1） and proliferation cell nuclear antigen （PCNA） in lesions of condylomata acuminata（CA）. Methods SP immunohistochemistry method was used to measure the expression of Stat 3, GluT-1 and PCNA in tissue samples from 40 cases of CA and 20 normal skin controls. Results The positivity rates of Stat 3, GluT-1 and PCNA were 85.0% （34/40）, 87.5%（35/40） and 85.0%（34/40）, respectively in CA tissue, 35.0% （7/20）, 30.0% （6/20）and 55.0% （11/20）, respectively in the control tissue; statistical difference was observed in these rates between the two groups （all P < 0.05）. The expression intensity of Stat 3, GluT-1 and PCNA was also higher in CA tissue than that in the controls. In addition, the expression intensity of PCNA was correlated with that of Stat 3 and GluT-1 in CA tissue （both P < 0.05）. Conclusions There is an overexpression of Stat 3, GluT-1 and PCNA in CA tissue, and the overexpression of Stat 3 and GluT-1 may be associated with the over-proliferation in CA.

Key words: Condyloma Acuminatum, STAT3, GLUT -1, PCNA