Abstract: Objective To detect the polymorphism of HCR gene,and to investigate the relationship of it with psoriasis vulgaris in Uigur population of Xinjiang Uigur Autonomous Region,China.Methods Blood samples were collected from 128 patients with psoriasis vulgaris and 132 healthy controls.DNA was extracted from the samples and subjected to test with PCR.Genotypes were identified with restriction frag-ment length polymorphism(PCR-RFLP)and gene sequencing.The genotype frequency was compared between the patient and control groups.Results A G/A polymorphism,including three genotypes of GG,GA and AA,was identified at position 1911 in exon 16 of HCR gene.There was no significant difference in genotype distribution or allele frequency in this site between the patient and control groups(P>0.05). Similarly,no significant difference was found in them when the patients of TypeⅠandⅡwere compared with the controls,respectively,or when male and female patients were compared with the controls,respectively.Conclusion No correlation is found between the polymorphism at position 1911 in exon 16 of HCR gene and development of non-familial psoriasis vulgaris in Uigur population of Xinjiang Uigur Autonomous Region.

Key words: Psoriasis, Genes,HCR, Alleles