Chinese Journal of Dermatology ›› 2007, Vol. 40 ›› Issue (3): 152-154.
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YU Bo1, CHENG Bin-zhu1, ZHONG Qi-li1, SHAO Yong1, LIAO Kang-huang2
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Abstract: Objective To detect the expression and aberrant mcthylation of T-cadherin in cutaneous basal cell carcinoma(BCC).Methods Skin tissues were resected during operation in light-exposed sites from 29 patients with BCC and 19 normal controls.The expression and aberrant mcthylation of T-cadherin were tested by immunohistochemical staining and methylation-specific polymerase chain reaction (MSP),respectively.Results Immunohistochemical staining showed that T-cadhcrin was expressed in 8 of 29(27.59%)BCC specimens, whereas in all(100%)normal controls, and there was a significant difference in T-cadherin positivity rates between the two groups(X2=24.46, P<0.05).The aberrant methylation of T-cadherin promoter region was detected in 9 BCC(37.93%)and in 1(5.26%)control specimen with significant difference between them(X2=4.62, P<0.05).Conclusion The decrease of T-cadherin expression, likely to be relavent to the aberrant methylation of T-cadherin promoter, might contribute to the pathogenesis of BCC.
Key words: Carcinoma, basal cell, Mcthylation, Cadherins
YU Bo, CHENG Bin-zhu, ZHONG Qi-li, SHAO Yong, LIAO Kang-huang. The expression and aberrant methylation of T-cadherin in cutaneous basal cell carcinoma[J].Chinese Journal of Dermatology, 2007, 40(3): 152-154.
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