Abstract: Objective To investigate and highlight the clinical features of photosensitive drug eruptions induced by Zhenju Jiangya Plan.Methods Thirty-eight cases of Zhenju Jiangya Pian-induced photosensitive drug eruptions were studied retrospectively.Medical records,clinical manifestations,phototest results and treatment strategies were assessed for these patients.Results The duration of drug exposure varied from 2 weeks to 2 years.The lesions in 36 patients were localized on sun exposed area,and mainly manifested as edematous erythematous plaques,and less frequently as papules and papulovesicles.In the remaining 2 cases,unexposed area was also involved,the skin lesions manifested as erythematous papules,papulovesicles and plaques.Phototesting was performed in 16 patients before treatment:7 had abnormal response to UVB,3 to UVA and UVB,and phototest results were normal in 6 patients.All patients discontinued the application of Zhenju Jiangya Pian,and were given oral nicotinamide and antihistamines as well as topical calamine lotion and corticosteroids cream.Conclusions The drug eruption induced by Zhenju Jiangya Pian is a phototoxic reaction,and presents as edematous erythematous plaques.It can also represent a photoallergic reaction,and manifested as polymorphous eruptions.

Key words: Drug eruptions, Thiazines, Zhenju Jiangya Pian